A mitochondria-targeted protonophoric uncoupler derived from fluorescein.
نویسندگان
چکیده
Linking decyl-triphenyl-phosphonium to fluorescein yields a fluorescent probe that accumulates in energized mitochondria, facilitates proton transfer across membranes and stimulates mitochondrial respiration. This features a mitochondria-targeted uncoupler, being of potential interest for therapeutic use against oxidative stress-related diseases.
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ورودعنوان ژورنال:
- Chemical communications
دوره 50 97 شماره
صفحات -
تاریخ انتشار 2014